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Clinical Update 12/14/2013 B-12 Deficiency and Acid Inhibitors A large, new study found the risk of vitamin B-12 deficiency to be significantly higher among people taking proton pump inhibitors (e.g., Prevacid, Prilosec) or H2-blockers (e.g., Pepcid, Zantac) than among those not taking these medications

FIGURE 10 Notably, SR18 also contains a potential trypsin cleavage site (Figure 10), and the HRMS data (Supplementary Figure S7) with a peak around 685 Da confirm that trypsin can cleave SR18 between Lys17 and Ala18, leaving the remaining crucial 17 residues intact

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Supplementation with high levels of L-carnitine (100-400 mg/kg/day) alleviates most symptoms

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