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Osteoarthritis is often dismissed as simple wear and tear, but we now understand that low-grade inflammation drives it too it isnt purely mechanical

While a causal relationship in humans has not been established, clinical vigilance is advised

Attribution requires a single-subtype recombinant line, selective antagonist controls, or a selective agonist comparator such as setmelanotide for MC4R

There is no cumulative effect on baseline sexual function MT-2 does not permanently alter dopamine synthesis or melanocortin receptor density

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