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Diabetes Care 29:2638-2643, 2006

11 Common barriers include discomfort with the mask, nasal dryness, and claustrophobia

One caveat while I discuss them separately, many times they overlap

In addition to the actions of GLP-1 discussed above, the long acting analogs have also in long-term cardiovascular outcome studies been demonstrated to result in reduced cardiovascular risk, so far only in patients with both T2DM and cardiovascular risk (95, 118, 119), but emerging evidence suggests that this may also apply to individuals without established heart disease

B., & Trevor, A

A thorough clinical evaluation is warranted to identify alternative explanations and ensure appropriate management