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Mitochondrial damage can trigger mitochondrial DNA (mtDNA) release, activating the cGAS-STING1 pathway and potentially contributing to ferroptosis, as observed with inducers like zalcitabine (116)
This matters most for tendons, ligaments, and cartilage, which have limited blood supply and dont respond well to standard anti-inflammatory approaches
However, in 2019, they only budgeted 15 million dollars towards ME/CFS research, whereas 111 million dollars and 94 million dollars was donated to MS and RA research, respectively (both of which already have drugs on the market)
At 205, hes been dropped like Khalil dropped him
Effect of circadian rhythm on metabolic processes and the regulation of energy balance
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