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Always tailor your approach based on personalized advice from your healthcare provider

The arcuate nucleus of the hypothalamus contains both appetite-stimulating (AgRP/NPY) and appetite-suppressing (POMC/CART) neurons

The SURMOUNT-1 study received the necessary ethical approvals from all study sites, obtained informed patient consent to participate and was conducted in accordance with the Declaration of Helsinki

What the trial data shows

If you experienced nausea or constipation on tirzepatide, semaglutide may reduce these issues, but temporary digestive adjustment symptomsmild diarrhea, slight stomach discomfort, or changes in appetite timingmay appear as your system calibrates

For a deeper look at this process, see our article on how semaglutides support weight loss