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Within the ARC, two primary, functionally antagonistic neuronal populations serve as first-order neurons: the anorexigenic pro-opiomelanocortin (POMC)-expressing neurons and the orexigenic agouti-related protein (AgRP)/neuropeptide Y (NPY)-expressing neurons [6]
GLP-1R-like immunoreactivity is present in the innervation of the human colon and is increased in biopsies from individuals with IBS [51]
Researchers have associated low levels with several medical conditions
Notably, certain plant-derived metabolites activate neuroprotective signaling pathways, such as the MAPK/NF-B system, (Md et al., 2021), and interact with estrogen receptor beta (ER), a known regulator of synaptic plasticity and neuroprotection (Cardona-Gmez et al., 2006)
Piteau S, Olver A, Kim SJ, Winter K, Pospisilik JA, Lynn F, et al
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