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doi: 10.1111/jfpp.13083 47
Note that semaglutide is very similar to GLP-1 and its mechanism of action is therefore limited to the activation of the receptor for this hormone, while tirzepatide is made up of an amalgam of amino acids found both in the GLP-1 (yellow circles), GIP (blue circles), and in the two hormones (green circles), which gives it a double agonist activity, capable of activating both receptors for these hormones
Indeed, high-dose liraglutide (3.0 mg daily) is already approved to support weight loss in both Europe and the US
How Ozempic and retatrutide work at the molecular level Understanding why these two medications produce such different results requires looking beneath the surface
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