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We encourage you to call your insurance provider to determine if the cost of vitamin B12 will be covered by your plan

You can take up to 1-1.5 grams daily if you have congestive heart failure, which requires higher amounts of supplementation

Within 24 hours my foot pain began to decrease

The results showed that mood improved and anxiety decreased at the 28mg/day dose.[ref] For patients with major depressive disorder, a study showed that the combination of curcumin (250mg) plus saffron (15mg/day) was effective in reducing depression scores, especially in people with atypical depression.[ref] In a comparison trial, saffron (30mg/day) was as effective as fluoxetine (Prozac) for mild to moderate depression after six weeks.[ref] Another study in adults with anxiety and depression looked at a 50mg saffron capsule taken twice a day

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Ethics declarations Competing interests HAC received research funds from Janssen, Eli Lilly, Fresenius Kabi and Pfizer, but nothing related to the current manuscript