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Polycyclic aromatic hydrocarbons (PAHs) found in cigarette smoke, for example, have been shown to decrease the activity of P450 enzymes, leading to a decrease in SAMe production and impaired DNA methylation

This is associated with a reduced capacity to handle large calcium loads and increased depolarization in response to calcium (Petersen et al., 2019)

These shifts in glutamate pools could be achieved without increasing oxidative stress or cell death

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Its designed to rapidly replenish these vitamins in your body when you cannot get enough from oral supplements or diet