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Much of the current evidence comes from animal studies, observational data, or small human studies
It should be stressed that the TIP peptide is a specific and direct activator of ENaC, unlike other used indirect activators, such as aldosterone, the latter of which can also exert ENaC-independent effects, which may chronically affect vascular function through the paracrine release of histamine (Schjerning et al., 2013)
Haaften, R
Quist DA, Diaz DE, Liu JJ, Karlin KD (2017) Activation of dioxygen by copper metalloproteins and insights from model complexes
