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The dosage of vitamin B12 injections is carefully tailored to meet each patients unique health needs
Standard titration protocol from clinical trials The Phase 2 NEJM trial used the following escalation schedule for the 12 mg dose group: Weeks 1 through 4: 2 mg once weekly (subcutaneous) Weeks 5 through 8: 4 mg once weekly Weeks 9 through 12: 8 mg once weekly Week 13 and beyond: 12 mg once weekly (maintenance dose) For the 8 mg target dose, the schedule was: Weeks 1 through 4: 2 mg once weekly Weeks 5 through 8: 4 mg once weekly Week 9 and beyond: 8 mg once weekly (maintenance dose) These titration schedules are not suggestions
For most people, a safe synthetic dose is about 2.0 milligrams (mg) each day
Only testing can tell you the answer, but a daily B12 injection schedule should be your starting point
Treatments may be given weekly or several times a week, often in combination with other nutrients such as magnesium and NAC
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