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Smaller doses tend to lead to fewer side effects, which is why doctors usually start patients on low GLP-1 doses

Importance of Long-Term Evaluation of Adverse Events The results on the long-term safety are important since it was initially a concern that DPP-4 inhibition may be associated with adverse events

And importantly, this should not be framed as an anti-GLP-1 conversation

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These medications require proper medical supervision and provider evaluation before starting therapy

For comparison, a moderate-deficit diet combined with resistance training typically loses only 15 to 25% of total weight as lean mass [8]