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In particular, neurons of the hindbrain found in the nucleus-tractus solitarius (NTS) secrete GLP-1 and activate hypothalamic neurons of the paraventricular nucleus (PVN), resulting in satiety (155, 156)

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Fat tissue was placed to reinforce the dural closure

27-34 PIONEER 1 PIONEER 1 compared the efficacy and safety of oral semaglutide as monotherapy with placebo in patients with T2DM managed by diet and exercise alone