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Rheumatol Int
In this off-target interaction, the triazole nitrogen engages the conserved glutamine residue, and the carboxamide side chain projects into a narrow lipophilic channel
They have a smooth surface and an irregular shape
Mitochondrial DNA deletions and neurodegeneration in multiple sclerosis
NRF2 is considered a central regulator of the cellular responses to changes in redox status but is also an important regulator of an array of processes that includes mitochondrial function, xenobiotic metabolism, carbohydrate, lipid, and iron metabolism, and DNA repair
Ovalle said
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