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The net result of treatment is an increased cellular uptake of LDL, since the intracellular synthesis of cholesterol is inhibited and cells are therefore dependent on extracellular sources of cholesterol
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Trends Pharmacol Sci 6:375378
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Carnitine supplementation if carnitine deficiency is detected, and addition of nitrogen scavenger medications, have been recommended as additional considerations within the therapeutic strategy [31]
Iron metabolism imbalance, lipid peroxidation and the System Xc-/GSH/GPx4 axis imbalance are the three hallmarks (28)
