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Although we expected the largest microbiome differences to occur in the lean control group relative to the obese control group, we found that the diet-switched groups exhibited a greater number of differences from the control groups than the control groups did from one another

K-means clustering Five clusters were used for k-means clustering, per the results of the sum of squared estimate of errors curve, on the ASV relative abundance data with clustering by animal (n = 25)

Scientific References (External Links) Nature Chemical Biology: Small molecule inhibitors of nicotinamide N-methyltransferase View Study Biochemical Pharmacology: Nicotinamide N-methyltransferase: A promising target for treating metabolic disorders View Study FASEB Journal: Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity in mice View Study Journal of Biological Chemistry: Inhibition of nicotinamide N-methyltransferase in vivo regulates cellular energy metabolism View Study

Adipocyte Models Adipocyte differentiation, intracellular metabolite, and lipid-related preclinical assays

Format: Powder (salt form) Compound class: Small molecule (NNMT inhibitor)

Even light activities, such as yoga or stretching, can help you feel more energized and focused