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13, 20, 26, 27, 48, 70, 71, 72 They are actively taken up into the brain 73 and can affect diverse physiological processes such as cell signaling, 71 neurotransmitter synthesis and release, 70 mitochondrial function, 20 lipid metabolism, 13, 74 immune function, 75 cellcell interactions 76 and gene expression
17 In 1987, phlorizin was found to alleviate hyperglycemia and restore insulin sensitivity in rats with diabetes, indicating its potential for T2D treatment
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The action is self-limiting as when the increased insulin release reduces plasma glucose, the ability of GLP-1 to act is turned off (44)
Remission of binge eating was achieved mainly through behavioral therapy, not the drug [129]
A typical sequence: Pre-op months 1 through 6
