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MITOCHONDRIA AND CELL DEATH Besides their fundamental role in energy generation, mitochondria also play a strategic role in the regulation of cell death, including apoptosis (caspase-dependent and independent) and necrosis

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Epididymal fat was subjected to haematoxylin and eosin (H&E) staining, immunohistochemical (IHC) staining, TG and glycerol content per cell, and SIRT1 activity assay (see ESM Methods)

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Acknowledgments The authors would like to acknowledge the use of generative AI technology, specifically Scholar AI, based on OpenAI's GPT-4 architecture, for revising the grammar of this paper

This review aims to elucidate T2DM related cognitive impairment mechanisms and propose potential mechanisms for GLP-1 cognitive enhancements