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What most people underestimate is how much the timing and composition of that last meal shapes the rest of the process." He pointed to a controlled crossover trial that was published in Cell Metabolism in 2022, suggesting that eating late at night actually increases hunger, lowers daytime energy expenditure, and pushes 'gene expression in fat tissue toward storage." Jones concluded: "In our clinic we build dinner around protein and fat because it holds patients full through the evening, protects lean mass during rapid weight loss, and makes the next day's intake easier to control

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Image courtesy of the Marc Lab, University of Utah