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Technique should follow the pen instructions Whichever site you choose, technique should follow the medication Instructions for Use

doi:10.1016/s2213-8587(25)00226-8 12.Yellow Card reaction profile: Tirzepatide

Timing Baseline Marker Fasting glucose Why it matters Gives a simple snapshot of current glucose control before interpreting appetite or weight changes

Note: If you are taking other medications for conditions like thyroid disease or blood pressure, the slowed digestion from GLP-1s makes timing even more important

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Safety and Monitoring - Always start with a low dose to assess tolerance