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In contrast to inhibiting H 2 S biosynthesis, some studies have addressed the advantage of poisoning cancer cells with high levels of H 2 S, by using donors that release H 2 S in the tumour and somehow block the most important signalling pathways sustaining cancer survival, such as PI3K and MAPK

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Downregulation of IL-6, TLR4, PTGS2, and IL-1 expression were also a consequence of BBR treatment [56]

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