While previous semaglutide/tirzepatide shortages have now been resolved, supply constraints remain a threat for future molecules especially for oral molecules that have much higher API requirements
the combination monitoring device opportunity here is significant, adherence tracking through pill dispensers with embedded sensors is already being spec'd by a few hardware teams The approval of Foundayo marks a pivotal shift in the metabolic landscape, as moving from weekly injections to a once-daily oral pill dismantles one of the largest patient barriers to long-term obesity management
One recent randomized control trial split participants into an exercise group, a GLP-1 group, and a combined group (7)
An invited commentary on this study, also published in JAMA Ophthalmology, challenges the idea that the increased risk of NAION among semaglutide users resulted directly from the medication
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The NAD+ dose is 100200 mg IM 2-3x per week