Frailty in individuals may include at least three of the following symptoms: unintentional weight loss, exhaustion (poor endurance), weakness (low grip strength), slowness, and physical inactivity (115)
Current evidence does not support withholding Ozempic solely based on autoimmune disease history, but individualised risk-benefit assessment remains essential
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A one-month trial may produce initial appetite suppression, yet most clinical evidence supports longer treatment windows to see significant, stable weight reduction and metabolic benefits