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Pharm Res 2022;183:106392
Specific data from some events of particular interes were reported by Colombijn et al., including severe hypoglycaemia (4% in the combination group vs
GLP-1R Lowers blood glucose by binding to GLP-1, mainly by stimulating insulin secretion and inhibiting glucagon secretion (Zheng et al., 2024)
Cagrilintides extended half-life derives from fatty acid modifications enabling albumin binding and delayed clearance, similar to modifications employed in long-acting insulin and GLP-1 analogs
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