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To assess long-term Exe4 secretion by hepatic cells with HITI-mediated knock-in, we transfected Hepa1-6 cells with either HITI donor DNA only (Donor) or the donor plus Cas9 DNAs (Donor+Cas9)

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Introduction If you have spent years struggling with persistent fatigue, unexplained weight gain, and a metabolism that feels like it has ground to a halt, you are certainly not alone

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doi: 10.1194/jlr.M072959

The Dual-Action Mechanism HMB activates mTOR (mammalian target of rapamycin) , the cellular machinery responsible for initiating muscle protein synthesis