Despite inherent limitations of observational data and potential for residual confounding, the results from these observational analyses support, in line with RCT findings, combining SGLT2is and GLP-1RAs to reduce cardiovascular events in patients with diabetes in routine clinical care [12, 23, 43, 63]
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Brown, for example, says she hasnt noticed an increase in GI problems when patients take both medicines, but it is theoretically possible. Side effects often improve over time as your body adjusts, but combining the two could make it harder to tolerate one or both
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Current trials are considering the effectiveness, efficacy, tolerance, and safety of a much higher dose of semaglutide: 7.2 milligrams instead of 2.4