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Research shows that people taking 96 to 200 mg/day of topiramate lose an average of 5 to 10% of their body weight
So, it really depends which guidelines youre looking at, but I would start considering it with a BMI of 30 or above. Idzik and MacLeod discuss much more related to obesity care, and Idzik ends their discussion on a note of optimism: As we've moved into new treatments for obesity, it's been refreshing as a provider who's cared for patients with obesity and metabolic disease for so long, and feeling like you wanted to work with them to help them in some way and just didn't have the toolsand now I feel like we're getting the tools in our tool chest to really make a difference in people's lives. If you are interested in learning more about endocrinology, enroll in Clinical Advantage: Endocrinology Certificate for Advanced Practice Providers Part 1, which offers 8.2 contact hours of continuing education credit
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A still unsolved issue, connected with the role of carnitine in modulating gene expression (Figure 1) is the link between mitochondria and nucleus: acetylcarnitine produced in mitochondria would reach the nucleus providing acetyl units (Figure 2)
These predispositions should be interpreted with a qualified healthcare providerthey indicate potential physiological patterns, not guaranteed medication response or outcome