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The phase 2 NEJM trial (Jastreboff et al., 2023) enrolled 338 adults with obesity or overweight without type 2 diabetes over a 48-week treatment period

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Emerging research suggests GLP-1 receptor agonists like semaglutide may have neuroprotective properties, with ongoing clinical trials investigating potential benefits in Alzheimer's disease

GLP-1 medications reduce appetite and slow gastric emptying, creating a prolonged feeling of fullness and leading to fewer calories consumed throughout the day

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