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The University of Washington STD/HIV Prevention Training Center reports that FDA-cleared NAATs demonstrate 100% sensitivity in women and 97.3% sensitivity in men using vaginal swabs and urine samples respectively. Testing methods include: Urine test preferred for men, non-invasive collection requiring first-catch morning sample Vaginal swab most accurate for women, can be self-collected or provider-collected Cervical swab collected during pelvic examination Urethral swab used in men when urine testing unavailable Pharyngeal swab throat testing for those with oral sexual exposure Rectal swab essential for individuals with receptive anal intercourse Results typically return within 24-72 hours, with rapid point-of-care NAATs providing results in approximately 30 minutes at some clinics