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BMJ 388 , e080679 (2025)
Documented middle tier: Licensed compounding pharmacies following USP with lot-level benzyl alcohol and sterility confirmation
This combination strategy is also highlighted in Novo Nordisk communications about regulatory filings, describing cagrilintide as the amylin analogue component paired with semaglutide
benefit: FDA only looked at risk, ignored benefits Off-label use: Doctors prescribe drugs off-label all the time Patient access: People are suffering and need options Regulatory capture: Big Pharma doesn't want cheap peptides competing The problem with these arguments: It's NOT off-label use Off-label only applies to FDA-approved drugs
Focus on habits that remain sustainable indefinitely rather than extreme measures requiring medication support
"Health Canada understands that there is considerable interest in lowering costs associated with this highly prescribed drug by introducing generic versions," spokesperson Mark Johnson said in an email to The Canadian Press
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