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Evoke and Evoke+: Two Phase 3 Randomized, Placebo-Controlled Trials of Semaglutide in Participants with Early-Stage Alzheimers Disease (NCT04777396 and NCT04777409)

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01 Cyclic Heptapeptide Lactam-bridged 7-amino-acid -MSH analog with activity at MC1R, MC3R, MC4R, and MC5R 02 99% HPLC Purity Every batch verified via high-performance liquid chromatography 03 USA Tested & Verified Third-party analytical testing performed in USA laboratories RESEARCH MT-2 Mechanism of Action in Research The MT-2 mechanism of action involves activation of multiple melanocortin receptor subtypes, triggering diverse downstream signaling cascades

Homma T, Fujii J