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Global disruption of Gclm results in mice (GCLM knockout) that have 15% of hepatic GSH levels seen in wild-type mice 16

The viral infection could also cause rapid T lymphocytopenia with functional impairment of T cells, which may onset OxS, pro-inflammatory state, cytokine production, and apoptosis 166,167

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The substrate-binding domain has a three-layer alpha/beta/alpha structure