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The high initial cost and technical complexity of the required equipment are significant barriers to large-scale industrial application (60)

As with any injectable therapy, personalized patient assessment and ongoing monitoring are essential for maximizing benefits and minimizing risk

To address any uncertainty surrounding whether patients had collected and then taken their prescribed medication, which is a major limitation of prescription data, we conducted a more stringent sensitivity analysis in subgroups of patients who had at least two prescriptions for their GLP-1 RA in the baseline period, suggesting that they had used their first prescription

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Note that this effect didnt seem to correlate with GLP-1 changes, though