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EHA 2023, 2023
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Some people use very small 'microdoses' to get benefits with fewer side effects, taken weekly or every other day
Avoiding lying down immediately after eating can also help reduce nausea and reflux symptoms
In an experimental study in rats using a protocol of CR (40%, 23 months), it was noticed that mitochondrial state 4 increased with age (with subsequent high ROS production) in the ad libitum fed, but not in the CR group (Sohal et al., 1994)
Future: Dedicated NASH Phase 3 Trial Expected Timeline IF Retatrutide Approved for Obesity/Diabetes (2028): 2027-2028: Dedicated NASH Phase 3 trial begins Population: Biopsy-confirmed NASH with fibrosis (F1-F3) Primary endpoint: NASH resolution without worsening fibrosis Baseline and Week 72-96 liver biopsies Duration: 18-24 months minimum 2029-2030: Trial results published 2030-2031: FDA approval decision for NASH indication Why This Matters Current Reality: Only one FDA-approved medication exists for NASH resmetirom (Rezdiffra), approved March 2024
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