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When a medication is on the FDA shortage list, compounding pharmacies may legally produce it under specific conditions

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This is the same phenomenon that makes alcohol more tempting on tirzepatide , but in reverse, everything becomes more tempting without it

In one randomized controlled trial that included 60 participants with a BMI of 35 or higher and type 2 diabetes for 5 years, 75% of those who underwent gastric bypass surgery and 95% of those who underwent a type of metabolic surgery known as biliopancreatic diversion were diabetes-free two years later, but no one treated with non-surgical interventions alone experienced diabetes remission (Mingrone 2012)