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Mice were placed in a stereotaxic frame (Kopf Instruments, USA), and a rectangular craniotomy was performed over the medial prefrontal cortex (AP, 13 mm and ML, 01.5 mm from the bregma) using a dental drill (Microtorque II, Ram Products, USA)

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Emerging clinical data suggest that low-dose naltrexone, when combined with sympathomimetic agents, yields additive reductions in caloric intake without proportionally increasing adverse events, though randomized trials remain limited

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Biliary excretion of excess iron in mice requires hepatocyte iron import by Slc39a14

But which method is more effective for improving skin tone, reducing pigmentation, and supporting overall skin wellness