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1,6 Despite normal secretion of GLP-1 and GIP, the incretin effect is reduced or absent in people with type 2 diabetes, with the insulin-stimulating effect of GIP being more impaired when compared to GLP-1
161 From a mechanistic perspective, inhibitory receptors typically harbor an ITIM or, in certain instances, an immunoreceptor tyrosine-based switch motif (ITSM) within their cytoplasmic tails
Never stop or adjust your medication without medical supervision, as this may affect your diabetes control or weight management goals
Related: Explore Transparent GLP-1 Pricing You may qualify for semaglutide or tirzepatide if your weight is affecting your health, function, or quality of life
PubMed, Horder, Jamie, et al
HDL Cholesterol GLP-1's effect on HDL is more modest (35 mg/dL increase) but meaningful for patients near the threshold
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