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Similar content being viewed by others 1 Introduction GLP-1 is an endogenous incretin hormone produced by intestinal L-cells that modulates postprandial glucose levels via glucose-dependent insulin production, offering intrinsic protection against hypoglycemia (Zander et al
[7] Inhibition of esophageal smooth muscle PDE5 can cause a marked reduction in esophageal motility as well as in lower esophageal sphincter (LES) tone
Clinical Note: These outcomes are based on trials involving FDA-approved semaglutide products
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