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For example, individuals with NAFLD exhibit increased intestinal permeability and prevalence of small intestine bacterial overgrowth, and these factors are associated with the severity of hepatic steatosis 19
Acknowledgements Not applicable
Invernizzi P, Miozzo M, Selmi C, Persani L, Battezzati PM, Zuin M, et al
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One review concluded that vitamin B12 plays a key role in fat metabolism, noting that a deficiency could be linked to increased fat accumulation and obesity ( Another animal study found that severe vitamin B12 deficiency led to a significant increase in body fat percentage and cholesterol levels in pregnant mice ( Whats more, one animal study showed that administering B vitamins to rats fed a high fat diet reduced weight gain and increased levels of several enzymes that influence metabolism, compared with a control group ( However, current evidence is lacking, and additional high quality studies are needed to determine how vitamin B12 may affect metabolism and body fat in humans
Key finding: Established subcutaneous bioavailability and favorable elimination profile, providing the pharmacokinetic foundation for all subsequent dosing protocols
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