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Rates of moderate to severe gastrointestinal adverse events were similar between those taking tirzepatide and semaglutide.

Immunofluorescence staining Immunofluorescence assays were used to assess the protein levels of cleaved-caspase3, p65, MMP3 and collagen II

Most reported side effects are mild

Constipation and diarrhea are also common, though they tend to be mild to moderate and manageable with dietary modifications

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But the specifics depend on your formulation type