It blocks an enzyme called NNMT, which consumes nicotinamide, a building block cells use to make NAD+
While AOD-9604 works systemically once absorbed, injecting near the target fat depot provides the highest local concentration during the brief peak activity window
On day 0, blood samples were collected via anesthesia-induced cardiac puncture and stored for plasma glycerol analysis
AOD-9604 Before and After: Realistic Timeline by Week Based on the available clinical data, the mechanism of action, and the pharmacokinetics of subcutaneous administration, here is a realistic timeline of what AOD-9604 users may experience
This binding triggers a cascade of events inside the adipocyte (fat cell) that ultimately results in lipolysis - the breakdown of stored triglycerides into free fatty acids that can be burned for energy
Methione: An essential amino acid, meaning that it cannot be synthesized in the body