However, observational studies suggest that whilst acute toxicity remains exceptionally rare, sustained very high levels of B12particularly from supplements or injectionsmay be associated with certain health concerns, though these are correlations rather than proven causal relationships
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An increase in both MMA and homocysteine distinguishes B 12 deficiency from folate deficiency because homocysteine alone increases in the latter
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Such mutation induces a hyperactivity of the LRRK2 kinase, known to be highly neurotoxic
