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This bioavailability gap means oral dosing requires higher amounts to achieve equivalent systemic exposure

Originally nominated for Category 2 (Bulk Substances that Raise Significant Safety Concerns), the withdrawal of these nominations would indicate that the FDA is reconsidering the validity of respective safety concerns

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[1] Particular concerns with multi-dose vials include dosing errors (confusion between mg, mL, or units) and contamination from repeated access

Native human PrP can bind up to six Cu 2+ ions, in a manner involving all the imidazole groups of the histidine residues located in the N-terminal repeats as well as His96 and His111