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Reported side effects are generally mild, including bloating, gas, and digestive discomfort, particularly when first starting the supplement

What makes metformin particularly well-suited to first-line use is its side effect profile

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10.1016/j.fsi.2018.03.024 84 ZuoH.YuanJ.YangL.LiangZ.WengS.HeJ.et al (2019)

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Monitoring Vitamin B12 During Retatrutide Treatment Baseline serum B12, full blood count, and folate should be measured before starting retatrutide