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avg body weight lost with Semaglutide (NEJM STEP 1 trial, 68 weeks) 2025% avg body weight lost with Tirzepatide (SURMOUNT-1, 7288 weeks) of semaglutide patients lost 5% of body weight (STEP 1 trial)of semaglutide patients lost 5% of body weight (STEP 1 trial) Week 14: Appetite reduction, smaller portions naturally Month 13: Steady fat loss begins, 12 lbs/week avg Month 36: Visible body composition change, reduced visceral fat 68 weeks: Average 14.9% total body weight reduction Ozempic for weight loss and Wegovy for weight loss produce comparable outcomes at equivalent doses

New survey documents patients experiences What does it feel like to take GLP-1s

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Key Points for Practice Extra vigilance is reasonable in patients with prior NAION or high optic nerve vulnerability

Adiponectin deficiency triggers bone loss by up-regulation of osteoclastogenesis and down-regulation of osteoblastogenesis