2021 [96], wherein GLP-1RA therapy was linked to a statistically significant reduction in heart failure risk
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Preliminary data published in June 2023 also suggests that GLP-1 drugs 'could modulate crucial pathways in the pathogenesis of inflammatory bowel disease (IBD), such as chronic inflammation circuits, intestinal tight junctions, and gut microbiome dysbiosis, setting the stage for human trials to investigate the role of these agents in the treatment of IBD among people with or without diabetes and obesity' (Arvanitakis, Theocharis, Popovic
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At 80 weeks , Lilly reported that participants on 12 mg achieved: 62.5% reaching 25% or greater weight loss 45.3% reaching 30% or greater weight loss 27.2% reaching 35% or greater weight loss 1 Those are unusually large responder rates for any anti-obesity medicine, especially in a pivotal trial