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It received FDA approval in 2014 for type 2 diabetes, and in 2020 an additional indication was added to reduce major adverse cardiovascular events in adults with type 2 diabetes
In particular, compounds containing -chloroacetamide moieties have shown potent inhibitory activity
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Long-Term Safety Clinical studies show GLP-1 medications are safe for long-term use when prescribed appropriately
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It is still a full agonist for all 3 receptors but it is selective for AMY1 so it is more likely to bind to this receptor while having more muted effects on the other two
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