The therapeutic benefit of these drugs in T2DM has raised interest in whether they affect the mechanism of bone metabolism (Zhang et al., 2018)
additionally, it is not recommended for individuals who are pregnant or planning to become pregnant
Creatine is generally considered safe and effective for supporting energy production during exercise
They work by mimicking a natural hormone in the body that helps regulate appetite, slows digestion, and promotes feelings of fullness
N Engl J Med 2022 PubMed 35658024 Expert consensus on managing GLP-1 GI side effects 40-70% of GLP-1 users experience GI side effects, occasionally reaching 85%
Protocol 1: moderate weight loss (10-15% body weight) Goal: Steady, sustainable weight loss with minimal side effects Tirzepatide approach: Standard escalation to 5-7.5 mg Hold at the dose where you achieve consistent weekly loss of 0.5-1% body weight Expected timeline: 24-36 weeks to target Likely maintenance dose: 5-7.5 mg Retatrutide approach: Standard escalation to 4 mg 4 mg delivered 12.9% weight loss at 24 weeks in trials Hold at 4 mg if achieving target rate Expected timeline: 20-30 weeks to target For moderate goals, both compounds work well at their lower dose ranges
