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Typically, the neurologic syndrome evolves over a period of several months, although the disease may take a more chronic course
Physiological pH and tonicity make it well-tolerated in rodent in vivo models
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What exists is preclinical, and it is thin: Rodent and in-vitro work described procognitive and synaptogenic effects (McCoy 2013, PMID 23055539 now under an Expression of Concern
Many allergy sufferers notice symptom fluctuation based on time of day, a pattern partly mediated by circadian immune cycling
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