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Pigmented lesions of the oral mucosa and perioral tissues: a flow-chart for the diagnosis and some recommendations for the management
Ideal candidates include those with BMI 30 (or 27 with comorbidities), stable cardiovascular history, normal kidney function, and no personal or family history of medullary thyroid cancer
de Jong, J
& Swami, O
It also signals several growth pathways that result in increased growth and it inhibits the pathway of cellular death
And its anabolic-related genes include fibroblast growth factor-21 (FGF21), SREBP-1c, fatty acid synthase (FAS), acetyl-CoA carboxylase (ACC-a), liver X receptor (LXR), suppressor of cytokine signaling-3 (SOCS-3), etc
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